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KMID : 1007020100080010056
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Korean Soceity of Osteroporosis
2010 Volume.8 No. 1 p.56 ~ p.63
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Bone Mineral Density and Bone Turnover Markers after One-year Teriparatide Treatment in Korean Postmenopausal Women with Osteoporosis
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Park Seon-Young
Bae Jae-Hoon
Kim Joo-Young
Oh Han-Jin
Joo Il-Woo
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Abstract
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Objectives: Recombinant teriparatide, a bone anabolic agent, is known to result in a net positive bone balance and reduce vertebral and nonvertebral fracture incidence. The objective of this study was to evaluate the changes of bone mineral density(BMD) and bone turnover markers after one-year teriparatide treatment in Korean postmenopausal women with osteoporosis.
Methods: The enrolled postmenopausal women with osteoporosis were administered teriparatide 20μg/ day injection for one year. BMD at the lumber spine and the hip were measured at baseline and after one year by dual-energy X-ray absorptiometry. Also, serum bone turnover markers, such as osteocalcin, C-telopeptide of collagen cross-links(CTX), and alkaline phosphatase were measured at baseline and after one year.
Results: Lumbar spine BMD increased from baseline(4.4%, P<0.01), but femoral neck BMD decreased from baseline(-9.7%, P<0.05). Bone turnover markers, such as osteocalcin(148.5%), CTX(67.6%), and alkaline phosphatase(56.7%) increased from baseline(P<0.001 for all).
Conclusion: One year of teriparatide treatment significantly increased lumbar spine BMD and bone turnover markers in Korean postmenopausal women with osteoporosis. The large-populated prospective study with longer administered period will be needed in the future.
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KEYWORD
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Osteoporosis, Teriparatide, Bone mineral density, Bone turnover marker, ostmenopausal women
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